Open AccessFeasibility of Embedding a Scalable, Virtually Enabled Biorepository in the Electronic Health Record for Precision Medicine
Author(s) -
Kimberley M. DeMerle,
Jason Kennedy,
Octavia M. Peck Palmer,
Emily Brant,
ChungChou H. Chang,
Robert P. Dickson,
David T. Huang,
Derek C. Angus,
Christopher Seymour
Publication year - 2021
Publication title -
jama network open
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.278
H-Index - 39
ISSN - 2574-3805
DOI - 10.1001/jamanetworkopen.2020.37739
Subject(s) - biorepository , electronic health record , scalability , precision medicine , embedding , computer science , medicine , data science , dermatology , artificial intelligence , health care , bioinformatics , pathology , biology , database , biobank , economics , economic growth
Key Points Question Is use of a large-scale, inexpensive electronic health record–embedded infrastructure that captures a high proportion of eligible participants and creates a virtually enabled clinical and biologic repository feasible? Findings In this cohort study of 1027 patients with sepsis, a novel infrastructure, termed virtually enabled biorepository and electronic health record–embedded, scalable cohort for precision medicine (VESPRE) was developed. VESPRE appeared to demonstrate feasible digital screening, successful enrollment, biologic sampling, and lower costs compared with a traditional study design. Meaning Results of this study suggest that VESPRE, an infrastructure embedded in the EHR that creates a virtually enabled biorepository, may be scalable across patients, centers, and laboratories at low incremental cost and burden.
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