Pharmacologic Interventions for Breathlessness in Patients With Advanced Cancer | Zendy

Josephine Feliciano | Zendy; Julie M. Waldfogel | Zendy; Ritu Sharma | Zendy; Allen Zhang | Zendy; Arjun Gupta | Zendy; Ramy Sedhom | Zendy; Jeff Day | Zendy; Eric B Bass | Zendy; Sydney M. Dy | Zendy

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Pharmacologic Interventions for Breathlessness in Patients With Advanced Cancer

Author(s) -

Josephine Feliciano,

Julie M. Waldfogel,

Ritu Sharma,

Allen Zhang,

Arjun Gupta,

Ramy Sedhom,

Jeff Day,

Eric B Bass,

Sydney M. Dy

Publication year - 2021

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2020.37632

Subject(s) - psychological intervention , cancer , medicine , intensive care medicine , physical therapy , nursing

Key Points Question What are the benefits and harms associated with pharmacologic interventions for managing breathlessness in adults with advanced cancer? Findings This systematic review and meta-analysis of 19 studies (17 randomized clinical trials and 2 retrospective studies) found that opioids and anxiolytics were not associated with improved breathlessness in patients with advanced cancer within the limits of the identified studies, which mainly focused on exertional breathlessness for opioids. Data on harms were too limited to draw conclusions. Meaning Although the existing data on opioids and pharmacologic interventions do not show an association with improved breathlessness in advanced cancer, they may be considered in selected patients in the context of potential harms and the evidence of an association of nonpharmacologic interventions with improved breathlessness.

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