Association of Nongenetic Factors With Breast Cancer Risk in Genetically Predisposed Groups of Women in the UK Biobank Cohort | Zendy

Kawthar Al Ajmi | Zendy; Artitaya Lophatana | Zendy; Krisztina Mekli | Zendy; William Ollier | Zendy; Kenneth Muir | Zendy

Open Access

Association of Nongenetic Factors With Breast Cancer Risk in Genetically Predisposed Groups of Women in the UK Biobank Cohort

Author(s) -

Kawthar Al Ajmi,

Artitaya Lophatana,

Krisztina Mekli,

William Ollier,

Kenneth Muir

Publication year - 2020

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2020.3760

Subject(s) - medicine , breast cancer , biobank , hazard ratio , demography , cohort , proportional hazards model , cohort study , prospective cohort study , oncology , cancer , confidence interval , genetics , biology , sociology

Key Points Question Is adhering to healthier lifestyle habits associated with a reduced breast cancer risk even among genetically predisposed groups? Findings This cohort study evaluated 2728 women with breast cancer and 88 489 controls and noted lower risks of breast cancer among women who practice a healthy lifestyle. Factors included in this lifestyle were exercise, healthy weight, low alcohol intake, and no oral contraceptive use, as well as avoiding or limiting use of hormonal replacement therapy to less than 5 years, among low, intermediate, and high genetic risk groups. Meaning Following a healthier lifestyle appears to be associated with a decreased level of risk of breast cancer across all strata of genetic risk.

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