Evaluation of Optimal Diastolic Blood Pressure Range Among Adults With Treated Systolic Blood Pressure Less Than 130 mm Hg

Key Points Question What are the safe and optimal diastolic blood pressure (DBP) ranges among adults with treated systolic blood pressure (SBP) of less than 130 mm Hg? Findings In this cohort study of 7515 patients from 2 randomized clinical trials who had treated SBP of less than 130 mm Hg, a DBP of less than 60 mm Hg was associated with increased cardiovascular risk and a DBP between 70 and 80 mm Hg was associated with lower cardiovascular risk. Meaning The findings suggest that a DBP of less than 60 mm Hg may be harmful and a DBP between 70 and 80 mm Hg is an optimal target for patients with treated SBP of less than 130 mm Hg; this topic merits further study.