Open AccessTrends in Hepatocellular Carcinoma Incidence and Risk Among Persons With HIV in the US and Canada, 1996-2015
Author(s) -
Jing Sun,
Keri N. Althoff,
Yuezhou Jing,
Michael A. Horberg,
Kate Buchacz,
M. John Gill,
Amy C. Justice,
Charles S. Rabkin,
James J. Goedert,
Keith Sigel,
Edward R. Cachay,
Lesley S. Park,
Joseph K. Lim,
H. Nina Kim,
Vincent Lo Re,
Richard D. Moore,
Timothy R. Sterling,
Marion G. Peters,
Chad J. Achenbach,
Michael J. Silverberg,
Jennifer E. Thorne,
Ángel M. Mayor,
Heidi M. Crane,
Mari M. Kitahata,
Marina B. Klein,
Gregory D. Kirk
Publication year - 2021
Publication title -
jama network open
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.278
H-Index - 39
ISSN - 2574-3805
DOI - 10.1001/jamanetworkopen.2020.37512
Subject(s) - medicine , interquartile range , hepatocellular carcinoma , cohort , incidence (geometry) , cart , hepatitis b virus , cancer registry , cohort study , hepatitis b , hepatitis c , medical record , cancer , immunology , oncology , virus , mechanical engineering , physics , optics , engineering
Key Points Question Has the incidence rate or risk for liver cancer among people with HIV increased with the widespread availability of combination antiretroviral therapy? Findings In this cohort study of 109 283 people with HIV in North America, the incidence rate of liver cancer increased between the early and modern combination antiretroviral therapy eras. People with HIV coinfected with hepatitis B virus and/or hepatitis C virus, those with higher HIV RNA levels and lower CD4 cell counts, and persons who inject drugs had a higher liver cancer risk. Meaning These findings underscore the importance of achieving immune recovery along with monitoring for and long-term management of viral hepatitis among people with HIV.
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