Open AccessClinical Characteristics and Outcomes Associated With Oral Anticoagulant Use Among Patients Hospitalized With Intracerebral Hemorrhage
Author(s) -
Ying Xian,
Shuaiqi Zhang,
Taku Inohara,
Maria V. GrauSepulveda,
Roland Matsouaka,
Eric D. Peterson,
Jonathan P. Piccini,
Eric E. Smith,
Kevin N. Sheth,
Deepak L. Bhatt,
Gregg C. Fonarow,
Lee H. Schwamm
Publication year - 2021
Publication title -
jama network open
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.278
H-Index - 39
ISSN - 2574-3805
DOI - 10.1001/jamanetworkopen.2020.37438
Subject(s) - medicine , warfarin , intracerebral hemorrhage , odds ratio , stroke (engine) , anticoagulant , modified rankin scale , cohort , cohort study , retrospective cohort study , atrial fibrillation , ischemic stroke , mechanical engineering , ischemia , subarachnoid hemorrhage , engineering
Key Points Question What is the association between prior oral anticoagulant use (factor Xa [FXa] inhibitors, warfarin, or none) and in-hospital outcomes among patients with nontraumatic intracerebral hemorrhage (ICH)? Findings In this registry-based cohort study of 219 701 patients with ICH, prior use of FXa inhibitors was associated with higher in-hospital mortality vs no prior anticoagulant use, although FXa inhibitors were associated with lower in-hospital mortality than warfarin. Meaning These findings suggest that patients with FXa inhibitor–associated ICH have a higher risk of mortality than those not taking an oral anticoagulant but better outcomes than those with warfarin-related ICH.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom