Assessment of RAS Dependency for BRAF Alterations Using Cancer Genomic Databases | Zendy

Yiqing Zhao | Zendy; Hanzhong Yu | Zendy; Cris Ida | Zendy; Kevin C. Halling | Zendy; Benjamin R. Kipp | Zendy; Katherine B. Geiersbach | Zendy; Kandelaria M. Rumilla | Zendy; Sounak Gupta | Zendy; MingTseh Lin | Zendy; Gang Zheng | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Assessment of RAS Dependency for BRAF Alterations Using Cancer Genomic Databases

Author(s) -

Yiqing Zhao,

Hanzhong Yu,

Cris Ida,

Kevin C. Halling,

Benjamin R. Kipp,

Katherine B. Geiersbach,

Kandelaria M. Rumilla,

Sounak Gupta,

MingTseh Lin,

Gang Zheng

Publication year - 2021

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2020.35479

Subject(s) - hras , neuroblastoma ras viral oncogene homolog , kras , cancer , genomics , biology , cancer research , gene , medicine , computational biology , database , colorectal cancer , genetics , genome , computer science

Key Points Question What is the in vivo RAS dependency of BRAF alterations in cancer samples? Findings In this cross-sectional study of genomic data analysis with more than 11 9000 cancer samples, it was found that current BRAF alteration classification does not accurately represent in vivo RAS dependency for non-V600 alterations. Meaning Results of this study suggest a need to revisit the classification of BRAF alterations, which has important clinical implications because personalized treatment strategies could be developed for RAS -dependent BRAF variant cancers based on different mechanisms of RAS activation.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research