Association of Serum Mannose With Acute Respiratory Distress Syndrome Risk and Survival | Zendy

Yongyue Wei | Zendy; Hui Huang | Zendy; Ruyang Zhang | Zendy; Zhaozhong Zhu | Zendy; Ying Zhu | Zendy; Lijuan Lin | Zendy; Xuesi Dong | Zendy; Liangmin Wei | Zendy; Xin Chen | Zendy; Zhonghua Liu | Zendy; Yang Zhao | Zendy; Li Su | Zendy; Feng Chen | Zendy; David C. Christiani | Zendy

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Association of Serum Mannose With Acute Respiratory Distress Syndrome Risk and Survival

Author(s) -

Yongyue Wei,

Hui Huang,

Ruyang Zhang,

Zhaozhong Zhu,

Ying Zhu,

Lijuan Lin,

Xuesi Dong,

Liangmin Wei,

Xin Chen,

Zhonghua Liu,

Yang Zhao,

Li Su,

Feng Chen,

David C. Christiani

Publication year - 2021

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2020.34569

Subject(s) - acute respiratory distress , respiratory distress , medicine , association (psychology) , mannose , mannan binding lectin , respiratory system , immunology , psychology , biology , lung , surgery , biochemistry , psychotherapist , lectin

Key Points Question Are serum metabolites associated with acute respiratory distress syndrome (ARDS) risk and survival among critically ill patients? Findings This cohort study, a 2-sample mendelian randomization analysis of 1630 participants, found that genetically regulated high-level serum mannose is associated with reduced ARDS risk and improved ARDS survival. Meaning This metabolome-wide association study identified mannose as a potential biomarker and therapeutic candidate for treating critically ill patients with ARDS.

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