Longitudinal Assessment of Mental Health Disorders and Comorbidities Across 4 Decades Among Participants in the Dunedin Birth Cohort Study | Zendy

Avshalom Caspi | Zendy; Renate Houts | Zendy; Antony Ambler | Zendy; Andrea Danese | Zendy; Maxwell L. Elliott | Zendy; Ahmad R. Hariri | Zendy; HonaLee Harrington | Zendy; Sean Hogan | Zendy; Richie Poulton | Zendy; Sandhya Ramrakha | Zendy; Line Jee Hartmann Rasmussen | Zendy; Aaron Reuben | Zendy; Leah S. RichmondRakerd | Zendy; Karen Sugden | Zendy; Jasmin Wertz | Zendy; Benjamin Williams | Zendy; Terrie E. Moffitt | Zendy

Open Access

Longitudinal Assessment of Mental Health Disorders and Comorbidities Across 4 Decades Among Participants in the Dunedin Birth Cohort Study

Author(s) -

Avshalom Caspi,

Renate Houts,

Antony Ambler,

Andrea Danese,

Maxwell L. Elliott,

Ahmad R. Hariri,

HonaLee Harrington,

Sean Hogan,

Richie Poulton,

Sandhya Ramrakha,

Line Jee Hartmann Rasmussen,

Aaron Reuben,

Leah S. RichmondRakerd,

Karen Sugden,

Jasmin Wertz,

Benjamin Williams,

Terrie E. Moffitt

Publication year - 2020

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2020.3221

Subject(s) - neurocognitive , mental health , cohort , medicine , population , pediatrics , psychiatry , cohort study , psychology , cognition , environmental health , pathology

Key Points Question Do mental disorder life histories shift among different successive disorders? Findings In this cohort study of 1037 participants in the Dunedin Study birth cohort, with assessments from ages 11 to 45 years, mental disorder life histories shifted among different successive internalizing, externalizing, and thought disorders. Mental disorder life histories are better described by age of onset, duration, and diversity of disorder than by any particular diagnosis. Meaning The finding that most mental disorder life histories involve different successive disorders helps to account for genetic and neuroimaging findings pointing to transdiagnostic causes and cautions against overreliance on diagnosis-specific research and clinical protocols.

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