Open AccessAssociation of Cognitive Function Trajectories in Centenarians With Postmortem Neuropathology, Physical Health, and Other Risk Factors for Cognitive Decline
Author(s) -
Nina Beker,
Andrea B. Ganz,
Marc Hulsman,
Thomas Klausch,
Ben Schmand,
Philip Scheltens,
Sietske A.M. Sikkes,
Henne Holstege
Publication year - 2021
Publication title -
jama network open
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.278
H-Index - 39
ISSN - 2574-3805
DOI - 10.1001/jamanetworkopen.2020.31654
Subject(s) - neuropathology , cognition , cognitive reserve , psychology , neuropsychology , cognitive test , dementia , cognitive decline , gerontology , medicine , clinical psychology , disease , psychiatry , pathology , cognitive impairment
Key Points Question Are cognitively healthy centenarians resilient against further cognitive decline? Findings In this cohort study of 330 self-reported cognitively healthy centenarians, cognitive trajectories revealed only a slight decline in memory functioning, while other domains remained stable over time. Centenarians maintained high levels of cognitive performance despite being exposed to varying levels of risk factors of cognitive decline, including postmortem Alzheimer disease–associated neuropathologies. Meaning These findings indicate that prolonged maintenance of cognitive functioning may be supported by mechanisms underlying resilience against risk factors of cognitive decline.
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