Association of Optical Coherence Tomography With Longitudinal Neurodegeneration in Veterans With Chronic Mild Traumatic Brain Injury | Zendy

Casey S. Gilmore | Zendy; Kelvin O. Lim | Zendy; Mona K. Garvin | Zendy; Jui-Kai Wang | Zendy; Johannes Ledolter | Zendy; Alicia Fenske | Zendy; Carolyn L. Gentz | Zendy; Julie Nellis | Zendy; Michael Armstrong | Zendy; Randy H. Kardon | Zendy

Open Access

Association of Optical Coherence Tomography With Longitudinal Neurodegeneration in Veterans With Chronic Mild Traumatic Brain Injury

Author(s) -

Casey S. Gilmore,

Kelvin O. Lim,

Mona K. Garvin,

Jui-Kai Wang,

Johannes Ledolter,

Alicia Fenske,

Carolyn L. Gentz,

Julie Nellis,

Michael Armstrong,

Randy H. Kardon

Publication year - 2020

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2020.30824

Subject(s) - traumatic brain injury , medicine , nerve fiber layer , retinal , cohort , neurodegeneration , veterans affairs , cohort study , longitudinal study , ophthalmology , disease , psychiatry , pathology

Key Points Question Do veterans with a history of mild traumatic brain injury show greater neurodegeneration over time compared with control veterans with no history of head injury? Findings In this longitudinal cohort study of 139 veterans with and without a history of mild traumatic brain injury, mild traumatic brain injury was associated with significantly greater thinning of the retinal nerve fiber layer over time. Meaning These findings suggest that structural neural loss in the visual system, as evidenced by thinning of the retinal nerve fiber layer, may be a useful biomarker of neurodegeneration following chronic mild traumatic brain injury.

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