Association of Improved Periconception Hemoglobin A1c With Pregnancy Outcomes in Women With Diabetes | Zendy

Alexander J. F. Davidson | Zendy; Alison L. Park | Zendy; Howard Berger | Zendy; Kazuyoshi Aoyama | Zendy; Ziv Harel | Zendy; Eyal Cohen | Zendy; Jocelynn L. Cook | Zendy; Joel G. Ray | Zendy

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Association of Improved Periconception Hemoglobin A_1c With Pregnancy Outcomes in Women With Diabetes

Author(s) -

Alexander J. F. Davidson,

Alison L. Park,

Howard Berger,

Kazuyoshi Aoyama,

Ziv Harel,

Eyal Cohen,

Jocelynn L. Cook,

Joel G. Ray

Publication year - 2020

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2020.30207

Subject(s) - medicine , pregnancy , obstetrics , gestational diabetes , glycated hemoglobin , glycemic , gestation , population , gestational age , diabetes mellitus , type 2 diabetes , endocrinology , genetics , environmental health , biology

Key Points Question Among women with prepregnancy diabetes, is improved glycemic control, from preconception to early pregnancy to midpregnancy, associated with reduced risk of adverse perinatal and maternal outcomes? Findings In this population-based cohort study of 3459 births among women with prepregnancy diabetes, a reduced risk was found for congenital anomalies, preterm birth, perinatal mortality, and severe maternal morbidity per 0.5% net absolute decline in serum glycated hemoglobin A 1c from preconception up to early pregnancy to midpregnancy. Meaning These findings suggest that women with prepregnancy diabetes who achieve a reduction in glycated hemoglobin A 1c from preconception up to early pregnancy to midpregnancy may have improved perinatal and maternal outcomes.

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