Progression of Behavioral Disturbances and Neuropsychiatric Symptoms in Patients With Genetic Frontotemporal Dementia | Zendy

Alberto Benussi | Zendy; Enrico Premi | Zendy; Stefano Gazzina | Zendy; Chiara Brattini | Zendy; Elisa Bonomi | Zendy; Antonella Alberici | Zendy; Lize C. Jiskoot | Zendy; John C. van Swieten | Zendy; Raquel SánchezValle | Zendy; Fermín Moreno | Zendy; Robert Laforce | Zendy; Caroline Graff | Zendy; Matthis Synofzik | Zendy; Daniela Galimberti | Zendy; Mario Masellis | Zendy; Maria Carmela Tartaglia | Zendy; James B. Rowe | Zendy; Elizabeth Finger | Zendy; Rik Vandenberghe | Zendy; Alexandre de Mendonça | Zendy; Fabrizio Tagliavini | Zendy; Isabel Santana | Zendy; Simon Ducharme | Zendy; Christopher Butler | Zendy; Alexander Gerhard | Zendy; Johannes Levin | Zendy; Adrian Danek | Zendy; Markus Otto | Zendy; Giovanni B. Frisoni | Zendy; Roberta Ghidoni | Zendy; Sandro Sorbi | Zendy; Isabelle Le Ber | Zendy; Florence Pasquier | Zendy; Georgia Peakman | Zendy; Emily Todd | Zendy; Martina Bocchetta | Zendy; Jonathan D. Rohrer | Zendy; Barbara Borroni | Zendy; Sónia Afonso | Zendy; Maria Rosário Almeida | Zendy; Sarah AnderlStraub | Zendy; Christin Andersson | Zendy; Anna Antonell | Zendy; Silvana Archetti | Zendy; Andrea Arighi | Zendy; Mircea Balasa | Zendy; Myriam Barandiarán | Zendy; Núria Bargalló | Zendy; Robert Bartha | Zendy; Benjamin Bender | Zendy; Luisa Benussi | Zendy; Maxime Bertoux | Zendy; Anne Bertrand | Zendy; Valentina Bessi | Zendy; Giuliano Binetti | Zendy; Sandra E. Black | Zendy; Sergi BorregoÉcija | Zendy; José Brás | Zendy; Alexis Brice | Zendy; Rose Bruffaerts | Zendy; Agnès Camuzat | Zendy; Marta Cañada | Zendy; Paola Caroppo | Zendy; David M. Cash | Zendy; Miguel CasteloBranco | Zendy; Olivier Colliot | Zendy; Rhian S. Convery | Zendy; Thomas Cope | Zendy; Maura Cosseddu | Zendy; Vincent Deramecourt | Zendy; María de Arriba | Zendy; Giuseppe Di Fede | Zendy; Alina Díez | Zendy; Diana Duro | Zendy; Chiara Fenoglio | Zendy; Camilla Ferrari | Zendy; Catarina B. Ferreira | Zendy; Nick C. Fox | Zendy; Morris Freedman | Zendy; Giorgio Fumagalli | Zendy; Aurélie Funkiewiez | Zendy; Alazne Gabilondo | Zendy; Roberto Gasparotti | Zendy; Serge Gauthier | Zendy; Giorgio Giaccone | Zendy; Ana Gorostidi | Zendy; Caroline Greaves | Zendy; Rita Guerreiro | Zendy; Carolin Heller | Zendy; Tobias Hoegen | Zendy; Begoña Indakoetxea | Zendy; Vesna Jelić | Zendy; HansOtto Karnath | Zendy; Ron Keren | Zendy; Grégory Kuchcinski | Zendy; Tobias Langheinrich | Zendy; Thibaud Lebouvier | Zendy; Maria João Leitão | Zendy; Albert Lladó | Zendy; Gemma Lombardi | Zendy; Sandra Loosli | Zendy; Carolina Maruta | Zendy; Simon Mead | Zendy; Lieke Meeter | Zendy; Gabriel Miltenberger | Zendy; Rick van Minkelen | Zendy; Sara Mitchell | Zendy; Katrina Moore | Zendy; Benedetta Nacmias | Zendy; Jennifer Nicholas | Zendy; Linn Öijerstedt | Zendy; Jaume Olives | Zendy; Sébastien Ourselin | Zendy; Alessandro Padovani | Zendy; Jessica Panman | Zendy; Janne M. Papma | Zendy; Michela Pievani | Zendy; Yolande A.L. Pijnenburg | Zendy; Cristina Polito | Zendy; Sara Prioni | Zendy; Catharina Prix | Zendy; Rosa Rademakers | Zendy; Veronica Redaelli | Zendy; Daisy Rinaldi | Zendy; Timothy Rittman | Zendy; Ekaterina Rogaeva | Zendy; Adeline Rollin | Zendy; Pedro RosaNeto | Zendy; Giacomina Rossi | Zendy; Martin N. Rossor | Zendy; Beatriz Santiago | Zendy; Dario Saracino | Zendy; Sabrina Sayah | Zendy; Elio Scarpini | Zendy; Sonja Schönecker | Zendy; Harro Seelaar | Zendy; Elisa Semler | Zendy; Rachelle Shafei | Zendy; Christen Shoesmith | Zendy; Miguel TábuasPereira | Zendy; Mikel Tainta | Zendy; Ricardo Taipa | Zendy; David F. TangWai | Zendy; David L. Thomas | Zendy; Paul Thompson | Zendy; Håkan Thonberg | Zendy; Carolyn Timberlake | Zendy; Pietro Tiraboschi | Zendy; Philip Van Damme | Zendy; Mathieu Vandenbulcke | Zendy; Michele Veldsman | Zendy; Ana Verdelho | Zendy; Jorge Villanúa | Zendy; Jason D. Warren | Zendy; Carlo Wilke | Zendy; Ione Woollacott | Zendy; Elisabeth Wlasich | Zendy; Henrik Zetterberg | Zendy; Miren Zulaica | Zendy

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Progression of Behavioral Disturbances and Neuropsychiatric Symptoms in Patients With Genetic Frontotemporal Dementia

Author(s) -

Alberto Benussi,

Enrico Premi,

Stefano Gazzina,

Chiara Brattini,

Elisa Bonomi,

Antonella Alberici,

Lize C. Jiskoot,

John C. van Swieten,

Raquel SánchezValle,

Fermín Moreno,

Robert Laforce,

Caroline Graff,

Matthis Synofzik,

Daniela Galimberti,

Mario Masellis,

Maria Carmela Tartaglia,

James B. Rowe,

Elizabeth Finger,

Rik Vandenberghe,

Alexandre de Mendonça,

Fabrizio Tagliavini,

Isabel Santana,

Simon Ducharme,

Christopher Butler,

Alexander Gerhard,

Johannes Levin,

Adrian Danek,

Markus Otto,

Giovanni B. Frisoni,

Roberta Ghidoni,

Sandro Sorbi,

Isabelle Le Ber,

Florence Pasquier,

Georgia Peakman,

Emily Todd,

Martina Bocchetta,

Jonathan D. Rohrer,

Barbara Borroni,

Sónia Afonso,

Maria Rosário Almeida,

Sarah AnderlStraub,

Christin Andersson,

Anna Antonell,

Silvana Archetti,

Andrea Arighi,

Mircea Balasa,

Myriam Barandiarán,

Núria Bargalló,

Robert Bartha,

Benjamin Bender,

Luisa Benussi,

Maxime Bertoux,

Anne Bertrand,

Valentina Bessi,

Giuliano Binetti,

Sandra E. Black,

Sergi BorregoÉcija,

José Brás,

Alexis Brice,

Rose Bruffaerts,

Agnès Camuzat,

Marta Cañada,

Paola Caroppo,

David M. Cash,

Miguel CasteloBranco,

Olivier Colliot,

Rhian S. Convery,

Thomas Cope,

Maura Cosseddu,

Vincent Deramecourt,

María de Arriba,

Giuseppe Di Fede,

Alina Díez,

Diana Duro,

Chiara Fenoglio,

Camilla Ferrari,

Catarina B. Ferreira,

Nick C. Fox,

Morris Freedman,

Giorgio Fumagalli,

Aurélie Funkiewiez,

Alazne Gabilondo,

Roberto Gasparotti,

Serge Gauthier,

Giorgio Giaccone,

Ana Gorostidi,

Caroline Greaves,

Rita Guerreiro,

Carolin Heller,

Tobias Hoegen,

Begoña Indakoetxea,

Vesna Jelić,

HansOtto Karnath,

Ron Keren,

Grégory Kuchcinski,

Tobias Langheinrich,

Thibaud Lebouvier,

Maria João Leitão,

Albert Lladó,

Gemma Lombardi,

Sandra Loosli,

Carolina Maruta,

Simon Mead,

Lieke Meeter,

Gabriel Miltenberger,

Rick van Minkelen,

Sara Mitchell,

Katrina Moore,

Benedetta Nacmias,

Jennifer Nicholas,

Linn Öijerstedt,

Jaume Olives,

Sébastien Ourselin,

Alessandro Padovani,

Jessica Panman,

Janne M. Papma,

Michela Pievani,

Yolande A.L. Pijnenburg,

Cristina Polito,

Sara Prioni,

Catharina Prix,

Rosa Rademakers,

Veronica Redaelli,

Daisy Rinaldi,

Timothy Rittman,

Ekaterina Rogaeva,

Adeline Rollin,

Pedro RosaNeto,

Giacomina Rossi,

Martin N. Rossor,

Beatriz Santiago,

Dario Saracino,

Sabrina Sayah,

Elio Scarpini,

Sonja Schönecker,

Harro Seelaar,

Elisa Semler,

Rachelle Shafei,

Christen Shoesmith,

Miguel TábuasPereira,

Mikel Tainta,

Ricardo Taipa,

David F. TangWai,

David L. Thomas,

Paul Thompson,

Håkan Thonberg,

Carolyn Timberlake,

Pietro Tiraboschi,

Philip Van Damme,

Mathieu Vandenbulcke,

Michele Veldsman,

Ana Verdelho,

Jorge Villanúa,

Jason D. Warren,

Carlo Wilke,

Ione Woollacott,

Elisabeth Wlasich,

Henrik Zetterberg,

Miren Zulaica

Publication year - 2021

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2020.30194

Subject(s) - frontotemporal dementia , dementia , medicine , psychiatry , physical medicine and rehabilitation , psychology , neuroscience , disease

Key Points Question Do behavioral and neuropsychiatric symptoms evolve differently in patients with distinct genetic variations for frontotemporal dementia? Findings In this cohort study of 232 patients with genetic frontotemporal dementia, patients with MAPT variants showed the highest frequency and severity of most behavioral symptoms compared with C9orf72 and GRN carriers. Anxiety and depression were most common in GRN and MAPT carriers; hallucinations, particularly auditory and visual, were most common in C9orf72 carriers. Meaning These findings suggest that behavioral and neuropsychiatric disturbances differ between the common frontotemporal dementia gene variations and have different trajectories through the course of disease.

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