Parent-Reported Symptoms and Medications Used Among Children With Severe Neurological Impairment | Zendy

James A. Feinstein | Zendy; Chris Feudtner | Zendy; Allison B. Blackmer | Zendy; Robert J. Valuck | Zendy; Diane L. Fairclough | Zendy; Jacqueline Holstein | Zendy; LiseAnne Gregoire | Zendy; Sadaf Samay | Zendy; Allison Kempe | Zendy

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Parent-Reported Symptoms and Medications Used Among Children With Severe Neurological Impairment

Author(s) -

James A. Feinstein,

Chris Feudtner,

Allison B. Blackmer,

Robert J. Valuck,

Diane L. Fairclough,

Jacqueline Holstein,

LiseAnne Gregoire,

Sadaf Samay,

Allison Kempe

Publication year - 2020

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2020.29082

Subject(s) - pediatrics , medicine , cognitive impairment , psychiatry , cognition

Key Points Question In children with severe neurological impairment (SNI) who cannot self-report, can comprehensive parent-reported symptom assessments inform medication use? Findings In this cross-sectional study of 100 children with SNI and polypharmacy, parents reported that children experienced multiple concurrent high-distress symptoms, notably irritability (65.0%), insomnia (55.0%), and pain (54.0%). Although higher symptom burdens were associated with increasing polypharmacy, opportunities existed to optimize pharmacotherapy; for example, among 54.0% of children with pain, only 61.0% were prescribed an analgesic. Meaning Comprehensive parent-reported symptom data paired with medication data could help clinicians identify targets for personalized symptom management, including underrecognized or undertreated symptoms.

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