Spectrum of Somatic Cancer Gene Variations Among Adults With Appendiceal Cancer by Age | Zendy

Andrea. Holowatyj | Zendy; Cathy Eng | Zendy; Wanqing Wen | Zendy; Kamran Idrees | Zendy; Xingyi Guo | Zendy

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Spectrum of Somatic Cancer Gene Variations Among Adults With Appendiceal Cancer by Age

Author(s) -

Andrea. Holowatyj,

Cathy Eng,

Wanqing Wen,

Kamran Idrees,

Xingyi Guo

Publication year - 2020

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2020.28644

Subject(s) - medicine , cancer , logistic regression , age of onset , demography , pediatrics , oncology , disease , sociology

Key Points Question What are the differences in somatic cancer gene variations in appendiceal cancer among adults based on age at disease onset? Findings In this cohort study of 385 patients diagnosed with appendiceal cancer with targeted clinical-grade sequencing data from the American Association for Cancer Project Genomics Evidence Neoplasia Information Exchange, patients who were diagnosed at age younger than 50 years harbored unique somatic variant patterns in PIK3CA , GNAS , SMAD3 , and TSC2 compared with those diagnosed at age 50 years and older. Meaning These findings suggest that appendiceal cancer diagnosed among young individuals harbors a distinct spectrum of somatic variations, which may yield clinical actionability in the development of targeted therapeutic modalities for young patients with appendiceal cancer.

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