Assessment of Plasma Amyloid-β42/40and Cognitive Decline Among Community-Dwelling Older Adults | Zendy

Kelly Virecoulon Giudici | Zendy; Philipe de Souto Barreto | Zendy; Sophie Guyonnet | Zendy; Yan Li | Zendy; Randall J. Bateman | Zendy; Bruno Vellas | Zendy

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Assessment of Plasma Amyloid-β_42/40and Cognitive Decline Among Community-Dwelling Older Adults

Author(s) -

Kelly Virecoulon Giudici,

Philipe de Souto Barreto,

Sophie Guyonnet,

Yan Li,

Randall J. Bateman,

Bruno Vellas

Publication year - 2020

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2020.28634

Subject(s) - interquartile range , cognitive decline , clinical dementia rating , medicine , geriatric depression scale , dementia , gerontology , cognition , cohort , depression (economics) , body mass index , effects of sleep deprivation on cognitive performance , psychology , disease , psychiatry , depressive symptoms , economics , macroeconomics

Key Points Question Is plasma amyloid-β 42/40 (Aβ 42/40 ) associated with cognitive decline among community-dwelling older adults with memory concerns? Findings In this cohort study of 483 participants from a randomized clinical trial, low plasma Aβ 42/40 ratio was significantly associated with more pronounced decline in composite cognitive score and Mini Mental State Examination score over time. Meaning In this study, low plasma Aβ 42/40 was associated with more pronounced decline in cognitive function over time, suggesting that this marker may be used to identify people at risk of cognitive decline and as an alternative to more complex and expensive measures.

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