Association Between Benzodiazepine Use With or Without Opioid Use and All-Cause Mortality in the United States, 1999-2015 | Zendy

Kevin Y. Xu | Zendy; Sarah M. Hartz | Zendy; Jacob T. Borodovsky | Zendy; Laura J. Bierut | Zendy; Richard A. Grucza | Zendy

Open Access

Association Between Benzodiazepine Use With or Without Opioid Use and All-Cause Mortality in the United States, 1999-2015

Author(s) -

Kevin Y. Xu,

Sarah M. Hartz,

Jacob T. Borodovsky,

Laura J. Bierut,

Richard A. Grucza

Publication year - 2020

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2020.28557

Subject(s) - medicine , national health and nutrition examination survey , national death index , propensity score matching , proportional hazards model , demography , opioid , cohort study , benzodiazepine , retrospective cohort study , cohort , medical prescription , hazard ratio , environmental health , population , confidence interval , pharmacology , receptor , sociology

Key Points Question Is benzodiazepine use, with or without opioid use, an independent risk factor for all-cause mortality or a marker for underlying conditions associated with death? Findings In this cohort study of 5212 individuals from a large, nationally representative data set, it was found that benzodiazepine use, with or without opioid use, was associated with a doubling in all-cause mortality risk in comparison with the use of low-risk antidepressants. These findings persisted even after adjustment for sociodemographic variables and comorbidity burden. Meaning This study suggests that benzodiazepine and opioid cotreatment may confer an increased long-term mortality risk; targeted interventions are needed to decrease overprescribing.

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