Open AccessAssociation Between Early Recovery of Kidney Function After Acute Kidney Injury and Long-term Clinical Outcomes
Author(s) -
Pavan K. Bhatraju,
Leila R. Zelnick,
Ver M. Chinchilli,
Dennis G. Moledina,
Steven G. Coca,
Chirag R. Parikh,
Amit X. Garg,
Chiyuan Hsu,
Alan S. Go,
Kathleen D. Liu,
T. Alp İkizler,
Edward D. Siew,
James S. Kaufman,
Paul L. Kimmel,
Jonathan Himmelfarb,
Mark M. Wurfel
Publication year - 2020
Publication title -
jama network open
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.278
H-Index - 39
ISSN - 2574-3805
DOI - 10.1001/jamanetworkopen.2020.2682
Subject(s) - acute kidney injury , renal function , medicine , kidney disease , dialysis , creatinine , renal replacement therapy , nephrology , prospective cohort study , cohort , intensive care medicine
Key Points Question Is the trajectory of kidney function within 72 hours after acute kidney injury associated with 5-year clinical outcomes, such as chronic kidney disease, dialysis, and death? Findings Among 1538 participants in this prospective multicenter cohort study, the early recovery pattern after acute kidney injury was associated with long-term outcomes. In adjusted analyses, patients with a nonresolving recovery pattern after acute kidney injury had a 51% greater risk for the composite kidney-specific clinical outcome compared with patients with a resolving acute kidney injury recovery pattern, independent of traditional criteria to risk stratify patients with acute kidney injury. Meaning This study’s finding suggest that the acute recovery pattern after development of acute kidney injury should be considered in evaluating the risk of long-term clinical outcomes.
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