Association of Neighborhood Deprivation With Epigenetic Aging Using 4 Clock Metrics

Key Points Question Is living in a neighborhood with a high concentration of household and population features characteristic of lower socioeconomic status (ie, a neighborhood with high deprivation) associated with epigenetic age acceleration across first- and second-generation clock metrics? Findings This cross-sectional study comprised 2630 women who had a sister with breast cancer but had not had breast cancer themselves. Those living in areas with the greatest compared with least neighborhood deprivation had higher epigenetic age acceleration estimated by Hannum, PhenoAge, and GrimAge clocks but not the Horvath clock. Meaning The results of this study suggest that residing in a neighborhood with a higher deprivation index appears to be reflected by methylation-based markers of aging.