Open AccessAssessment of Birth Defects and Cancer Risk in Children Conceived via In Vitro Fertilization in the US
Author(s) -
Barbara Luke,
Morton B. Brown,
Hazel B. Nichols,
Maria J. Schymura,
Marilyn L. Browne,
Sarah C. Fisher,
Nina E. Forestieri,
Chandrika Rao,
Mahsa M. Yazdy,
Susan T. Gershman,
Mary K. Ethen,
Mark A. Canfield,
Melanie Williams,
Ethan Wantman,
Sergio Oehninger,
Kevin J. Doody,
Michael L. Eisenberg,
Valerie L. Baker,
Philip J. Lupo
Publication year - 2020
Publication title -
jama network open
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.278
H-Index - 39
ISSN - 2574-3805
DOI - 10.1001/jamanetworkopen.2020.22927
Subject(s) - medicine , hazard ratio , in vitro fertilisation , cancer , obstetrics , live birth , cancer registry , demography , proportional hazards model , cohort , cohort study , gynecology , pregnancy , confidence interval , biology , surgery , genetics , sociology
Key Points Question Is the incidence of birth defects and childhood cancer among children conceived via in vitro fertilization different from that among children conceived naturally? Findings In this population-based cohort study of 1 053 415 children in 4 states, the presence of a birth defect and the number of birth defects were associated with an increased risk of childhood cancer. The increased risk was 2-fold higher for children conceived via in vitro fertilization than for children conceived naturally. Meaning In this study, cancer risk increased in the presence of birth defects at a higher rate in children conceived via in vitro fertilization than in children conceived naturally; further study is warranted.
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