National Poison Center Calls Before vs After Availability of High-Dose Acetaminophen (Paracetamol) Tablets in Switzerland

Key Points Question Was the introduction of the 1000-mg formulation of oral acetaminophen tablets associated with an increased number of acetaminophen-related calls to the National Poison Centre in Switzerland? Findings This cross-sectional study using a quasi-experimental interrupted time series analysis of 15 790 acetaminophen-related poisoning calls identified a significant increase in the number of calls following the date 1000-mg tablets were authorized, particularly for calls regarding accidental poisonings. The reported poisonings in the postintervention period were more likely to include doses exceeding 10 000 mg, indicating potential for severe hepatoxicity. Meaning The results of this study support the need for public health measures to restrict the availability of the 1000-mg acetaminophen tablet to minimize the potential for accidental acetaminophen-related harm.