Cost-effectiveness of Population-Wide Genomic Screening for Hereditary Breast and Ovarian Cancer in the United States | Zendy

Gregory F. Guzauskas | Zendy; Shawn Garbett | Zendy; Zilu Zhou | Zendy; Scott J. Spencer | Zendy; Hadley Stevens Smith | Zendy; Jing Hao | Zendy; Dina Hassen | Zendy; Susan Snyder | Zendy; John Graves | Zendy; Josh F. Peterson | Zendy; Marc S. Williams | Zendy; David L. Veenstra | Zendy

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Cost-effectiveness of Population-Wide Genomic Screening for Hereditary Breast and Ovarian Cancer in the United States

Author(s) -

Gregory F. Guzauskas,

Shawn Garbett,

Zilu Zhou,

Scott J. Spencer,

Hadley Stevens Smith,

Jing Hao,

Dina Hassen,

Susan Snyder,

John Graves,

Josh F. Peterson,

Marc S. Williams,

David L. Veenstra

Publication year - 2020

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2020.22874

Subject(s) - medicine , breast cancer , population , ovarian cancer , cancer , incidence (geometry) , family history , cost effectiveness , gynecology , quality adjusted life year , demography , oncology , obstetrics , environmental health , risk analysis (engineering) , physics , sociology , optics

Key Points Question Is it cost-effective to implement population-wide genomic screening for hereditary breast and ovarian cancer (HBOC)? Findings This decision analytical model study found that genomic screening for HBOC among unselected women may be cost-effective depending on the age distribution of the women screened. Cascade testing of first-degree relatives added a modest improvement in clinical and economic value. Meaning Population-level genomic screening for HBOC targeting women aged 20 to 35 years could be considered in settings in which the outcomes of screening can be evaluated, particularly to avoid a reduction in mammography screening among patients with negative test results.

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