Comparison of Acetaminophen (Paracetamol) With Ibuprofen for Treatment of Fever or Pain in Children Younger Than 2 Years | Zendy

Eunicia Tan | Zendy; Irene Braithwaite | Zendy; Christopher J. D. McKinlay | Zendy; Stuart R Dalziel | Zendy

Open Access

Comparison of Acetaminophen (Paracetamol) With Ibuprofen for Treatment of Fever or Pain in Children Younger Than 2 Years

Author(s) -

Eunicia Tan,

Irene Braithwaite,

Christopher J. D. McKinlay,

Stuart R Dalziel

Publication year - 2020

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2020.22398

Subject(s) - medicine , acetaminophen , antipyretic , ibuprofen , pediatrics , wheeze , adverse effect , analgesic , guideline , randomized controlled trial , medline , meta analysis , asthma , anesthesia , pharmacology , pathology , political science , law

Key Points Question Are there differences in the antipyretic, analgesic, and safety profiles of acetaminophen (paracetamol) compared with ibuprofen for the short-term treatment of fever or pain in children younger than 2 years? Findings In this meta-analysis of 19 studies with 241 138 participants, ibuprofen, compared with acetaminophen, was associated with reduced temperature at less than 4 hours and 4 to 24 hours and less pain at 4 to 24 hours. Adverse events were uncommon. Meaning In this study, use of ibuprofen vs acetaminophen for the treatment of fever or pain in children younger than 2 years was associated with reduced temperature and less pain within the first 24 hours of treatment, with equivalent safety.

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