Incidence and Mortality of Second Primary Cancers in Danish Patients With Retinoblastoma, 1943-2013 | Zendy

Pernille A. Gregersen | Zendy; Maja Halgren Olsen | Zendy; Steen F. Urbak | Zendy; Mikkel Funding | Zendy; Susanne Oksbjerg Dalton | Zendy; Jens Overgaard | Zendy; Jan Alsner | Zendy

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Incidence and Mortality of Second Primary Cancers in Danish Patients With Retinoblastoma, 1943-2013

Author(s) -

Pernille A. Gregersen,

Maja Halgren Olsen,

Steen F. Urbak,

Mikkel Funding,

Susanne Oksbjerg Dalton,

Jens Overgaard,

Jan Alsner

Publication year - 2020

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2020.22126

Subject(s) - retinoblastoma , medicine , interquartile range , incidence (geometry) , retrospective cohort study , cumulative incidence , epidemiology , cancer registry , heritability , cohort , pediatrics , danish , oncology , biology , genetics , linguistics , physics , philosophy , gene , optics

Key Points Question Are heritability and treatment associated with the incidence of second primary cancer in Danish retinoblastoma survivors? Findings In this national cohort study of 323 patients in Denmark diagnosed with retinoblastoma, the incidence and mortality of second primary cancer were significantly higher in patients with heritable retinoblastoma vs patients with nonheritable retinoblastoma. The data did not show an increased risk in patients with heritable disease who were treated with external radiotherapy. Meaning The findings of this study suggest that patients with a genetic predisposition to retinoblastoma may be at greater greatest risk for developing second primary cancer later in life.

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