Association of Parental Preconception Exposure to Phthalates and Phthalate Substitutes With Preterm Birth | Zendy

Yu Zhang | Zendy; Vicente Mustieles | Zendy; Jennifer J. Yland | Zendy; Joseph M. Braun | Zendy; Paige L. Williams | Zendy; Jill Attaman | Zendy; Jennifer B. Ford | Zendy; Antonia M. Calafat | Zendy; Russ Hauser | Zendy; Carmen Messerlian | Zendy

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Association of Parental Preconception Exposure to Phthalates and Phthalate Substitutes With Preterm Birth

Author(s) -

Yu Zhang,

Vicente Mustieles,

Jennifer J. Yland,

Joseph M. Braun,

Paige L. Williams,

Jill Attaman,

Jennifer B. Ford,

Antonia M. Calafat,

Russ Hauser,

Carmen Messerlian

Publication year - 2020

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2020.2159

Subject(s) - phthalate , medicine , pregnancy , obstetrics , offspring , gestation , gestational age , prospective cohort study , gynecology , biology , chemistry , organic chemistry , genetics

Key Points Question Are paternal and maternal preconception urinary metabolite concentrations of phthalates and phthalate substitutes associated with singleton preterm birth? Findings In this preconception cohort study of 420 singleton infants, maternal preconception urinary concentrations of di-(2-ethylhexyl) phthalate and di(isononyl)cyclohexane-1,2-dicarboxylate (a nonphthalate plasticizer substitute) were associated with an increased risk of preterm birth. Fathers’ preconception concentrations of these biomarkers were not associated with preterm birth in offspring. Meaning Female exposure to select plasticizers during the preconception period may be a potential risk factor for adverse pregnancy outcomes.

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