Prevalence of Hypothyroidism in Patients With Erdheim-Chester Disease | Zendy

Skand Shekhar | Zendy; Ninet Sinaii | Zendy; Jorge A. IrizarryCaro | Zendy; William A. Gahl | Zendy; Juvianee EstradaVeras | Zendy; Rahul Dave | Zendy; Georgios Z. Papadakis | Zendy; Amit Tirosh | Zendy; Brent S. Abel | Zendy; Joanna Kłubo-Gwieździńska | Zendy; Monica C. Skarulis | Zendy; Bernadette R. Gochuico | Zendy; Kevin O’Brien | Zendy; Fady HannahShmouni | Zendy

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Prevalence of Hypothyroidism in Patients With Erdheim-Chester Disease

Author(s) -

Skand Shekhar,

Ninet Sinaii,

Jorge A. IrizarryCaro,

William A. Gahl,

Juvianee EstradaVeras,

Rahul Dave,

Georgios Z. Papadakis,

Amit Tirosh,

Brent S. Abel,

Joanna Kłubo-Gwieździńska,

Monica C. Skarulis,

Bernadette R. Gochuico,

Kevin O’Brien,

Fady HannahShmouni

Publication year - 2020

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2020.19169

Subject(s) - medicine , erdheim–chester disease , histiocytosis , magnetic resonance imaging , thyroid , levothyroxine , central hypothyroidism , pediatrics , endocrinology , pathology , disease , radiology

Key Points Question What is the prevalence of hypothalamic-pituitary-thyroid dysfunction in patients with Erdheim-Chester disease (ECD)? Findings In this cross-sectional study of 61 patients with ECD, the prevalence of central and primary hypothyroidism was 9.8% and 18.0%, respectively, in patients with ECD, higher than the corresponding rates of 0.1% and 4.7%, respectively, in the community. Meaning The findings of this study suggest that clinicians should consider screening for hypothyroidism in patients with ECD.

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