Prognostic Value of Prerevascularization Fractional Flow Reserve Mediated by the Postrevascularization Level | Zendy

Rikuta Hamaya | Zendy; Murray A. Mittleman | Zendy; Masahiro Hoshino | Zendy; Yoshihisa Kanaji | Zendy; Tadashi Murai | Zendy; Joo Myung Lee | Zendy; Ki Hong Choi | Zendy; Junjie Zhang | Zendy; Fei Ye | Zendy; Xiaobo Li | Zendy; Zhen Ge | Zendy; ShaoLiang Chen | Zendy; Tsunekazu Kakuta | Zendy

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Prognostic Value of Prerevascularization Fractional Flow Reserve Mediated by the Postrevascularization Level

Author(s) -

Rikuta Hamaya,

Murray A. Mittleman,

Masahiro Hoshino,

Yoshihisa Kanaji,

Tadashi Murai,

Joo Myung Lee,

Ki Hong Choi,

Junjie Zhang,

Fei Ye,

Xiaobo Li,

Zhen Ge,

ShaoLiang Chen,

Tsunekazu Kakuta

Publication year - 2020

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2020.18162

Subject(s) - conventional pci , fractional flow reserve , medicine , interquartile range , percutaneous coronary intervention , cardiology , coronary angiography , myocardial infarction

Key Points Question To what extent is the association of pre–percutaneous coronary intervention (PCI) fractional flow reserve (FFR) with clinical outcomes explained by the association of pre-PCI FFR with post-PCI FFR? Findings In this cohort study of 1488 patients, low pre-PCI FFR was significantly associated with target vessel failure but not mediated by post-PCI FFR. Meaning The results of this study suggest that the prognostic information of pre-PCI FFR may not be associated with the results of PCI, represented as post-PCI FFR, indicating that the prognostic information of pre-PCI FFR may mainly reflect the global atherosclerotic burden of the artery, not the extent of the modifiable epicardial stenosis.

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