Open AccessAssociation of Epigenetic Metrics of Biological Age With Cortical Thickness
Author(s) -
Amy L. Proskovec,
Michael T Rezich,
Jennifer O’Neill,
Brenda Morsey,
Tina Wang,
Trey Ideker,
Susan Swindells,
Howard S. Fox,
Tony W. Wilson
Publication year - 2020
Publication title -
jama network open
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.278
H-Index - 39
ISSN - 2574-3805
DOI - 10.1001/jamanetworkopen.2020.15428
Subject(s) - dnam , biological age , neuroimaging , population , medicine , demography , brain aging , linear regression , psychology , gerontology , biology , neuroscience , dna methylation , disease , statistics , biochemistry , gene expression , mathematics , environmental health , sociology , gene
Key Points Question Are DNA methylation–based metrics of biological age associated with cortical thickness, and does a biological age acceleration index capture unique changes in cortical thinning compared with chronological age measures? Findings In this cross-sectional study of 82 healthy adults, both biological and chronological age were associated with widespread cortical thinning, but biological age acceleration was also associated with additional changes in cortical morphological features. Older biological age relative to chronological age was associated with accentuated thinning within prefrontal and temporal regions. Meaning These findings suggest that DNA methylation–based biological age may yield additional insight into healthy and pathological cortical aging compared with chronological age alone.
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