Effects of Candesartan vs Lisinopril on Neurocognitive Function in Older Adults With Executive Mild Cognitive Impairment | Zendy

Ihab Hajjar | Zendy; Maureen Okafor | Zendy; Darius McDaniel | Zendy; Malik Obideen | Zendy; Elizabeth Dee | Zendy; Mahsa Shokouhi | Zendy; Arshed A. Quyyumi | Zendy; Allan I. Levey | Zendy; Felicia C. Goldstein | Zendy

Open Access

Effects of Candesartan vs Lisinopril on Neurocognitive Function in Older Adults With Executive Mild Cognitive Impairment

Author(s) -

Ihab Hajjar,

Maureen Okafor,

Darius McDaniel,

Malik Obideen,

Elizabeth Dee,

Mahsa Shokouhi,

Arshed A. Quyyumi,

Allan I. Levey,

Felicia C. Goldstein

Publication year - 2020

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2020.12252

Subject(s) - candesartan , lisinopril , neurocognitive , medicine , montreal cognitive assessment , randomized controlled trial , trail making test , psychology , cardiology , physical therapy , cognition , blood pressure , neuropsychology , angiotensin ii , cognitive impairment , psychiatry , angiotensin converting enzyme

Key Points Question What are the comparative neurocognitive effects of an angiotensin receptor blocker, candesartan, and an angiotensin-converting enzyme inhibitor, lisinopril, on adults with hypertension and executive mild cognitive impairment? Findings In this randomized clinical trial of 176 adults with hypertension, 12-month treatment with candesartan was associated with improvement in executive function and episodic memory compared with lisinopril. Meaning These findings suggest that among older adults with hypertension and mild cognitive impairment, treatment with candesartan provided better neurocognitive effects compared with lisinopril despite equivalent blood pressure levels.

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