Clinical and Immune Features of Hospitalized Pediatric Patients With Coronavirus Disease 2019 (COVID-19) in Wuhan, China | Zendy

Huan Wu | Zendy; Hongmin Zhu | Zendy; Chunhui Yuan | Zendy; Cong Yao | Zendy; Wei Luo | Zendy; Xin Shen | Zendy; Jun Wang | Zendy; Jianbo Shao | Zendy; Yun Xiang | Zendy

Open Access

Clinical and Immune Features of Hospitalized Pediatric Patients With Coronavirus Disease 2019 (COVID-19) in Wuhan, China

Author(s) -

Huan Wu,

Hongmin Zhu,

Chunhui Yuan,

Cong Yao,

Wei Luo,

Xin Shen,

Jun Wang,

Jianbo Shao,

Yun Xiang

Publication year - 2020

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2020.10895

Subject(s) - medicine , interquartile range , gastroenterology , pneumonia , creatine kinase , lactate dehydrogenase , alanine transaminase , covid-19 , disease , infectious disease (medical specialty) , biochemistry , chemistry , enzyme

Key Points Question What are the immunologic features of pediatric patients with pneumonia caused by coronavirus disease 2019 (COVID-19)? Findings In this single-center case series involving 157 pediatric patients with COVID-19, systemic inflammation rarely occurred. Patients with moderate disease had higher interleukin 10 levels and lower neutrophil levels than patients with mild disease. Meaning The results of this study suggest that dysregulation of immune response may be involved in the pathologic process of COVID-19; gaining a deeper understanding of the role of neutrophils, CD4 + T cells, and B cells in the pathogenesis of severe acute respiratory syndrome coronavirus 2 infection could be important for the clinical management of COVID-19.

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