Effect of Pregnenolone vs Placebo on Self-reported Chronic Low Back Pain Among US Military Veterans | Zendy

Jennifer C. Naylor | Zendy; Jason D. Kilts | Zendy; Lawrence J. Shampine | Zendy; Gillian J. Parke | Zendy; Henry R. Wagner | Zendy; Steven T. Szabo | Zendy; Karen D. Smith | Zendy; Trina B. Allen | Zendy; Emily G. Telford-Marx | Zendy; Charlotte Dunn | Zendy; Brian T. Cuffe | Zendy; Susan H. O’Loughlin | Zendy; Christine E. Marx | Zendy

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Effect of Pregnenolone vs Placebo on Self-reported Chronic Low Back Pain Among US Military Veterans

Author(s) -

Jennifer C. Naylor,

Jason D. Kilts,

Lawrence J. Shampine,

Gillian J. Parke,

Henry R. Wagner,

Steven T. Szabo,

Karen D. Smith,

Trina B. Allen,

Emily G. Telford-Marx,

Charlotte Dunn,

Brian T. Cuffe,

Susan H. O’Loughlin,

Christine E. Marx

Publication year - 2020

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2020.0287

Subject(s) - placebo , pregnenolone , medicine , psychology , physical therapy , psychiatry , alternative medicine , steroid , pathology , hormone

Key Points Question Does adjunctive treatment with pregnenolone improve chronic low back pain in Iraq- and Afghanistan-era US military veterans? Findings The use of pregnenolone in this randomized, double-blind, placebo-controlled clinical trial in 94 veterans with chronic low back pain resulted in a significant reduction in pain intensity ratings after 4 weeks of treatment. Meaning These findings suggest that pregnenolone may be a safe and effective adjunctive treatment for veterans with chronic low back pain.

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