Association of Long-term Exposure to Elevated Lipoprotein(a) Levels With Parental Life Span, Chronic Disease–Free Survival, and Mortality Risk | Zendy

Benoît J. Arsenault | Zendy; William Pelletier | Zendy; Yannick Kaiser | Zendy; Nicolas Perrot | Zendy; Christian Couture | Zendy; KayTee Khaw | Zendy; Nicholas J. Wareham | Zendy; Yohan Bossé | Zendy; Philippe Pîbarot | Zendy; Erik S.G. Stroes | Zendy; Patrick Mathieu | Zendy; Sébastien Thériault | Zendy; S. Matthijs Boekholdt | Zendy

Open Access

Association of Long-term Exposure to Elevated Lipoprotein(a) Levels With Parental Life Span, Chronic Disease–Free Survival, and Mortality Risk

Author(s) -

Benoît J. Arsenault,

William Pelletier,

Yannick Kaiser,

Nicolas Perrot,

Christian Couture,

KayTee Khaw,

Nicholas J. Wareham,

Yohan Bossé,

Philippe Pîbarot,

Erik S.G. Stroes,

Patrick Mathieu,

Sébastien Thériault,

S. Matthijs Boekholdt

Publication year - 2020

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2020.0129

Subject(s) - biobank , mendelian randomization , medicine , demography , genome wide association study , european prospective investigation into cancer and nutrition , disease , single nucleotide polymorphism , hazard ratio , prospective cohort study , gerontology , genetics , biology , confidence interval , genotype , genetic variants , sociology , gene

Key Points Question Is long-term exposure to elevated lipoprotein(a) levels associated with shorter life span? Findings In this genetic association study including 139 362 participants, 2-sample mendelian randomization showed that genetically elevated lipoprotein(a) levels were associated with parental life span. Measured lipoprotein(a) levels were also associated with all-cause mortality in a population-based study. Meaning Results of this study provide additional knowledge on the potential biological determinants of human longevity phenotypes and a rationale for trials of lipoprotein(a)-lowering therapy in individuals with high lipoprotein(a) levels.

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