Association of Serum Folate Levels With Cardiovascular Mortality Among Adults With Rheumatoid Arthritis

Key Points Question Are serum folate levels associated with cardiovascular mortality risk among adults with rheumatoid arthritis (RA)? Findings In this cohort study including 683 patients with RA, those with serum folate levels between 4.3 and 8.2 ng/mL and greater than 8.2 ng/mL had 48% and 56% lower cardiovascular mortality risk, respectively, compared with patients who had serum folate levels less than 4.3 ng/mL after adjusting for demographic characteristics, body mass index, C-reactive protein level, smoking, RA medication use, and comorbid conditions. Meaning In this study, serum folate levels of at least 4.3 ng/mL were associated with lower cardiovascular mortality risk among patients with RA.