Longitudinal Maintenance of Cognitive Health in Centenarians in the 100-plus Study | Zendy

Nina Beker | Zendy; Sietske A.M. Sikkes | Zendy; Marc Hulsman | Zendy; Niccoló Tesi | Zendy; Sven J. van der Lee | Zendy; Philip Scheltens | Zendy; Henne Holstege | Zendy

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Longitudinal Maintenance of Cognitive Health in Centenarians in the 100-plus Study

Author(s) -

Nina Beker,

Sietske A.M. Sikkes,

Marc Hulsman,

Niccoló Tesi,

Sven J. van der Lee,

Philip Scheltens,

Henne Holstege

Publication year - 2020

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2020.0094

Subject(s) - cognitive decline , gerontology , cognition , hazard ratio , medicine , demography , longitudinal study , cohort study , survivorship curve , successful aging , cohort , proportional hazards model , psychology , disease , dementia , confidence interval , population , environmental health , psychiatry , sociology , pathology

Key Points Question Is it possible to identify centenarians who escape cognitive decline? Findings In this cohort study of 340 centenarians, most individuals who scored 26 or higher on the Mini-Mental State Examination at study inclusion maintained this level of performance for at least 2 years of follow-up, despite having risk factors associated with cognitive decline. This group represents less than 10% of the centenarians in the Dutch population. Meaning Using the Mini-Mental State Examination, this study identified a small subgroup of centenarians who maintained high levels of cognitive functioning and showed resilience against risk factors associated with cognitive decline.

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