Association of Leukocyte Telomere Length With Mortality Among Adult Participants in 3 Longitudinal Studies | Zendy

Konstantin G. Arbeev | Zendy; Simon Verhulst | Zendy; Troels Steenstrup | Zendy; Jeremy D. Kark | Zendy; Olivia Bagley | Zendy; Charles Kooperberg | Zendy; Alexander P. Reiner | Zendy; Shih-Jen Hwang | Zendy; Daniel Levy | Zendy; Annette L. Fitzpatrick | Zendy; Kaare Christensen | Zendy; Anatoliy I. Yashin | Zendy; Abraham Aviv | Zendy

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Association of Leukocyte Telomere Length With Mortality Among Adult Participants in 3 Longitudinal Studies

Author(s) -

Konstantin G. Arbeev,

Simon Verhulst,

Troels Steenstrup,

Jeremy D. Kark,

Olivia Bagley,

Charles Kooperberg,

Alexander P. Reiner,

Shih-Jen Hwang,

Daniel Levy,

Annette L. Fitzpatrick,

Kaare Christensen,

Anatoliy I. Yashin,

Abraham Aviv

Publication year - 2020

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2020.0023

Subject(s) - medicine , framingham heart study , telomere , demography , concordance , cohort study , cohort , gerontology , disease , framingham risk score , genetics , biology , dna , sociology

Key Points Question Is leukocyte telomere length associated with the natural life span of contemporary humans? Findings This cohort study included 3259 participants from 3 longitudinal studies, of whom 1525 died during the follow-up period. Leukocyte telomere length–associated mortality from noncancer causes increased as participants aged, approaching their age at death. Meaning These data suggest that leukocyte telomere length is associated with a life span limit among contemporary humans.

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