Feasibility of Core Antimicrobial Stewardship Interventions in Community Hospitals | Zendy

Deverick J. Anderson | Zendy; Shera Watson | Zendy; Rebekah W. Moehring | Zendy; Lauren Komarow | Zendy; Matthew Finnemeyer | Zendy; Rebekka M. Arias | Zendy; Jacqueline Huvane | Zendy; Carol Hill | Zendy; Nancie Deckard | Zendy; Daniel J. Sexton | Zendy

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Feasibility of Core Antimicrobial Stewardship Interventions in Community Hospitals

Author(s) -

Deverick J. Anderson,

Shera Watson,

Rebekah W. Moehring,

Lauren Komarow,

Matthew Finnemeyer,

Rebekka M. Arias,

Jacqueline Huvane,

Carol Hill,

Nancie Deckard,

Daniel J. Sexton

Publication year - 2019

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2019.9369

Subject(s) - antimicrobial stewardship , medicine , psychological intervention , formulary , pharmacist , piperacillin , piperacillin/tazobactam , clinical pharmacy , tazobactam , intensive care medicine , emergency medicine , family medicine , antibiotics , pharmacy , nursing , antibiotic resistance , imipenem , genetics , bacteria , microbiology and biotechnology , pseudomonas aeruginosa , biology

Key Points Question Are 2 core Infectious Diseases Society of America–recommended antimicrobial stewardship strategies, preauthorization (PA) and postprescription audit and review (PPR), feasible in community hospitals? Findings Among 2692 patients in this multicenter nonrandomized clinical trial with crossover design, PPR and a modified PA strategy were feasible; strict PA was not feasible. Postprescription audit and review decreased antimicrobial use and identified more inappropriate antimicrobial therapy, led to more direct interactions with clinicians, and resulted in more antimicrobial de-escalation than the modified PA strategy. Meaning Postprescription audit and review is a feasible and effective strategy for antimicrobial stewardship in settings with limited resources and expertise.

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