Longitudinal Association of Depression Symptoms With Cognition and Cortical Amyloid Among Community-Dwelling Older Adults | Zendy

Jennifer R. Gatchel | Zendy; Jennifer S. Rabin | Zendy; Rachel F. Buckley | Zendy; Joseph J. Locascio | Zendy; Yakeel T. Quiroz | Zendy; HyunSik Yang | Zendy; Patrizia Vannini | Zendy; Rebecca E. Amariglio | Zendy; Dorene M. Rentz | Zendy; Michael J Properzi | Zendy; Nancy J. Donovan | Zendy; Deborah Blacker | Zendy; Keith A. Johnson | Zendy; Reisa A. Sperling | Zendy; Gad A. Marshall | Zendy

Open Access

Longitudinal Association of Depression Symptoms With Cognition and Cortical Amyloid Among Community-Dwelling Older Adults

Author(s) -

Jennifer R. Gatchel,

Jennifer S. Rabin,

Rachel F. Buckley,

Joseph J. Locascio,

Yakeel T. Quiroz,

HyunSik Yang,

Patrizia Vannini,

Rebecca E. Amariglio,

Dorene M. Rentz,

Michael J Properzi,

Nancy J. Donovan,

Deborah Blacker,

Keith A. Johnson,

Reisa A. Sperling,

Gad A. Marshall

Publication year - 2019

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2019.8964

Subject(s) - depression (economics) , geriatric depression scale , cognition , cognitive decline , cohort , longitudinal study , medicine , pittsburgh compound b , alzheimer's disease , cohort study , positron emission tomography , psychology , gerontology , disease , dementia , depressive symptoms , psychiatry , pathology , nuclear medicine , economics , macroeconomics

Key Points Question Do changing depressive symptoms over time in the presence of cortical amyloid—an in vivo marker of Alzheimer disease pathology—relate to changes in cognition in older adults? Findings In longitudinal data from a cohort study of 276 older adults, all of whom were cognitively unimpaired and had at most mild depression at study entry, worsening depressive symptoms over 2 to 7 years in the presence of cortical amyloid were significantly associated with declining cognition. Meaning Concurrent changes in depression and cognition among older adults with higher cortical amyloid suggest that depressive symptoms may serve as targets in delaying the clinical symptoms of Alzheimer disease.

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