Open AccessComparison of Multiparametric Magnetic Resonance Imaging and Targeted Biopsy With Systematic Biopsy Alone for the Diagnosis of Prostate Cancer
Author(s) -
Martha Elwenspoek,
Athena L. Sheppard,
Matthew D. F. McInnes,
Samuel William David Merriel,
Edward Rowe,
Richard J. Bryant,
Jenny Donovan,
Penny Whiting
Publication year - 2019
Publication title -
jama network open
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.278
H-Index - 39
ISSN - 2574-3805
DOI - 10.1001/jamanetworkopen.2019.8427
Subject(s) - medicine , biopsy , prostate cancer , radiology , transrectal ultrasonography , prostate biopsy , magnetic resonance imaging , systematic review , clinical trial , meta analysis , randomized controlled trial , cancer , medline , political science , law
Key Points Question Is prebiopsy magnetic resonance imaging combined with targeted biopsy associated with improved detection of clinically significant prostate cancer compared with transrectal ultrasonography–guided systematic prostate biopsy alone? Findings This systematic review and meta-analysis of 7 randomized clinical trials (2582 patients) demonstrates that prebiopsy magnetic resonance imaging combined with targeted biopsy is associated with improved detection of clinically significant prostate cancer and reduced numbers of biopsy cores per procedure, while potentially avoiding unnecessary biopsies. Meaning These findings support the introduction of prebiopsy magnetic resonance imaging into the diagnostic pathway for biopsy-naive men with suspected prostate cancer.
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