Association Between Neonatal Neuroimaging and Clinical Outcomes in Zika-Exposed Infants From Rio de Janeiro, Brazil | Zendy

KaraLee Pool | Zendy; Kristina Adachi | Zendy; Stellios Karnezis | Zendy; Noriko Salamon | Zendy; Tahmineh Romero | Zendy; Karin NielsenSaines | Zendy; Sheila Moura Pone | Zendy; Márcia Cristina Bastos Boëchat | Zendy; Mitsue Senra Aibe | Zendy; Tallita Gomes da Silva | Zendy; Carla Trevisan Martins Ribeiro | Zendy; M. Ines Boechat | Zendy; Patrícia Brasil | Zendy; Andréa Zin | Zendy; Irena Tsui | Zendy; Stephanie L. Gaw | Zendy; Pedro Daltro | Zendy; Bianca Guedes Ribeiro | Zendy; Tatiana Fazecas | Zendy; Luiz Celso Hygino da Cruz | Zendy; Renata Nogueira | Zendy; Zilton Vasconcelos | Zendy; José Paulo Pereira | Zendy; Tania Saad Salles | Zendy; Claudia Neves Barbosa | Zendy; Weiqiang Chen | Zendy; SuanSin Foo | Zendy; Jae U. Jung | Zendy; Maria Elisabeth Lopes Moreira | Zendy; Marcos Vinícius da Silva Pone | Zendy

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Association Between Neonatal Neuroimaging and Clinical Outcomes in Zika-Exposed Infants From Rio de Janeiro, Brazil

Author(s) -

KaraLee Pool,

Kristina Adachi,

Stellios Karnezis,

Noriko Salamon,

Tahmineh Romero,

Karin NielsenSaines,

Sheila Moura Pone,

Márcia Cristina Bastos Boëchat,

Mitsue Senra Aibe,

Tallita Gomes da Silva,

Carla Trevisan Martins Ribeiro,

M. Ines Boechat,

Patrícia Brasil,

Andréa Zin,

Irena Tsui,

Stephanie L. Gaw,

Pedro Daltro,

Bianca Guedes Ribeiro,

Tatiana Fazecas,

Luiz Celso Hygino da Cruz,

Renata Nogueira,

Zilton Vasconcelos,

José Paulo Pereira,

Tania Saad Salles,

Claudia Neves Barbosa,

Weiqiang Chen,

SuanSin Foo,

Jae U. Jung,

Maria Elisabeth Lopes Moreira,

Marcos Vinícius da Silva Pone

Publication year - 2019

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2019.8124

Subject(s) - neuroimaging , zika virus , medicine , association (psychology) , pediatrics , environmental health , psychology , psychiatry , virology , virus , psychotherapist

Key Points Question Are neuroimaging findings of infants exposed to Zika virus associated with infant clinical outcomes and gestational age of antenatal Zika virus infection? Findings In this cohort study of 110 infants with confirmed or suspected antenatal exposure to Zika virus evaluated at a referral center from 2015 to 2016, 96% of abnormal neuroimaging occurred among Zika virus–exposed infants with severe clinical findings at birth; however, 10% of infants without severe clinical manifestations also had neuroimaging abnormalities. In addition, an increased risk of abnormal imaging was associated with Zika virus exposure in the first trimester compared with later trimesters. Meaning Neuroimaging of infants exposed to Zika virus is an important part of evaluating infants with a history of Zika virus in utero exposure, particularly for those exposed in the first trimester.

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