Association of Coronary Artery Calcium With Long-term, Cause-Specific Mortality Among Young Adults | Zendy

Michael D. Miedema | Zendy; Zeina Dardari | Zendy; Khurram Nasir | Zendy; Ron Blankstein | Zendy; Thomas Knickelbine | Zendy; Sandra Oberembt | Zendy; Leslee J. Shaw | Zendy; John A. Rumberger | Zendy; Erin D. Michos | Zendy; Alan Rozanski | Zendy; Daniel S. Berman | Zendy; Matthew J. Budoff | Zendy; Michael J. Blaha | Zendy

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Association of Coronary Artery Calcium With Long-term, Cause-Specific Mortality Among Young Adults

Author(s) -

Michael D. Miedema,

Zeina Dardari,

Khurram Nasir,

Ron Blankstein,

Thomas Knickelbine,

Sandra Oberembt,

Leslee J. Shaw,

John A. Rumberger,

Erin D. Michos,

Alan Rozanski,

Daniel S. Berman,

Matthew J. Budoff,

Michael J. Blaha

Publication year - 2019

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2019.7440

Subject(s) - medicine , hazard ratio , diabetes mellitus , coronary artery disease , hyperlipidemia , cohort , cohort study , mortality rate , cardiology , confidence interval , endocrinology

Key Points Question What is the prevalence of coronary artery calcium (CAC) in adults aged 30 to 49 years with clinical indications for CAC scoring, and is CAC associated with long-term, cause-specific mortality in these young adults? Findings In this cohort study of 22 346 individuals from the CAC Consortium with clinical indications for CAC, 34.4% had prevalent CAC. The risk of death from coronary heart disease, cardiovascular disease, or all-cause mortality was significantly higher for those with elevated CAC scores, even after multivariable adjustment. Meaning Coronary artery calcium may potentially be used as a tool to aid decision-making among select young adults at elevated lifetime risk for cardiovascular disease; the relatively high prevalence of CAC in younger adults with cardiovascular risk factors reinforces the need for the adoption of healthy lifestyle behaviors early in life.

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