Association of Repetitive Transcranial Magnetic Stimulation Treatment With Subgenual Cingulate Hyperactivity in Patients With Major Depressive Disorder | Zendy

Itay Hadas | Zendy; Yinming Sun | Zendy; Pantelis Lioumis | Zendy; Reza Zomorrodi | Zendy; Brett D. M. Jones | Zendy; Daphne Voineskos | Zendy; Jonathan Downar | Zendy; Paul B. Fitzgerald | Zendy; Daniel M. Blumberger | Zendy; Zafiris J. Daskalakis | Zendy

Open Access

Association of Repetitive Transcranial Magnetic Stimulation Treatment With Subgenual Cingulate Hyperactivity in Patients With Major Depressive Disorder

Author(s) -

Itay Hadas,

Yinming Sun,

Pantelis Lioumis,

Reza Zomorrodi,

Brett D. M. Jones,

Daphne Voineskos,

Jonathan Downar,

Paul B. Fitzgerald,

Daniel M. Blumberger,

Zafiris J. Daskalakis

Publication year - 2019

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2019.5578

Subject(s) - transcranial magnetic stimulation , major depressive disorder , anterior cingulate cortex , dorsolateral prefrontal cortex , depression (economics) , anxiety , mood , psychology , medicine , psychiatry , prefrontal cortex , neuroscience , stimulation , cognition , economics , macroeconomics

Key Points Question Is repetitive transcranial magnetic stimulation associated with changes in subgenual cingulate cortex (SGC) activity in patients with major depressive disorder (MDD)? Findings This diagnostic study, which compared 30 patients with MDD and 30 healthy controls, found that using transcranial magnetic stimulation combined with electroencephalography, SGC activity in patients with MDD was significantly higher compared with healthy controls. After active repetitive transcranial magnetic stimulation, SGC hyperactivity in patients with MDD was attenuated toward the levels of healthy controls. Meaning These SGC-localized findings support SGC hyperactivity as a central construct in the pathophysiology of MDD, which future work might develop into a clinically significant biological target.

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