Association of Net Ultrafiltration Rate With Mortality Among Critically Ill Adults With Acute Kidney Injury Receiving Continuous Venovenous Hemodiafiltration | Zendy

Raghavan Murugan | Zendy; Samantha J. Kerti | Zendy; Chung-Chou H. Chang | Zendy; Martin Gallagher | Zendy; Gilles Clermont | Zendy; Paul M. Palevsky | Zendy; John A. Kellum | Zendy; Rinaldo Bellomo | Zendy

Open Access

Association of Net Ultrafiltration Rate With Mortality Among Critically Ill Adults With Acute Kidney Injury Receiving Continuous Venovenous Hemodiafiltration

Author(s) -

Raghavan Murugan,

Samantha J. Kerti,

Chung-Chou H. Chang,

Martin Gallagher,

Gilles Clermont,

Paul M. Palevsky,

John A. Kellum,

Rinaldo Bellomo

Publication year - 2019

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2019.5418

Subject(s) - medicine , interquartile range , renal replacement therapy , acute kidney injury , critically ill , mortality rate

Key Points Question Is the net ultrafiltration (ie, fluid removal) rate associated with survival among critically ill patients with acute kidney injury? Findings In this secondary analysis of a randomized clinical trial involving 1434 critically ill patients treated with continuous venovenous hemodiafiltration, a net ultrafiltration rate greater than 1.75 mL/kg/h compared with a net ultrafiltration rate less than 1.01 mL/kg/h was significantly associated with lower 90-day risk-adjusted survival. Meaning Among critically ill patients with acute kidney injury being treated with continuous venovenous hemodiafiltration, net ultrafiltration rates greater than 1.75 mL/kg/h were associated with increased mortality.

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