Assessment of the Role of Carotid Atherosclerosis in the Association Between Major Cardiovascular Risk Factors and Ischemic Stroke Subtypes | Zendy

Sarah Parish | Zendy; Matthew Arnold | Zendy; Robert Clarke | Zendy; Huaidong Du | Zendy; Eric Yuk Fai Wan | Zendy; Om Kurmi | Zendy; Yiping Chen | Zendy; Canqing Yu | Zendy; Zheng Bian | Zendy; Rory Collins | Zendy; Liming Li | Zendy; Zhengming Chen | Zendy

Open Access

Assessment of the Role of Carotid Atherosclerosis in the Association Between Major Cardiovascular Risk Factors and Ischemic Stroke Subtypes

Author(s) -

Sarah Parish,

Matthew Arnold,

Robert Clarke,

Huaidong Du,

Eric Yuk Fai Wan,

Om Kurmi,

Yiping Chen,

Canqing Yu,

Zheng Bian,

Rory Collins,

Liming Li,

Zhengming Chen

Publication year - 2019

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2019.4873

Subject(s) - medicine , stroke (engine) , diabetes mellitus , cardiology , blood pressure , cohort , population , disease , biobank , ischemic stroke , ischemia , bioinformatics , environmental health , mechanical engineering , engineering , biology , endocrinology

Key Points Question What is the role of carotid atherosclerosis in the association between major cardiovascular risk factors and different ischemic stroke subtypes? Findings In this population-based cohort study of Chinese adults with subtyping of incident ischemic strokes, carotid artery ultrasonographic measurements were recorded in 23 973 participants after 8 years’ follow-up. Blood pressure was associated with all ischemic stroke subtypes independently of carotid plaque burden, but after adjustment for blood pressure, carotid plaque burden was associated with probable large artery and lacunar stroke but not with probable cardioembolic stroke. Meaning Drug treatments targeting atherosclerosis may affect the risk of ischemic stroke subtypes to different extents.

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