Development and Validation of an Esophageal Squamous Cell Carcinoma Detection Model by Large-Scale MicroRNA Profiling | Zendy

Kazuki Sudo | Zendy; Ken Kato | Zendy; Juntaro Matsuzaki | Zendy; Narikazu Boku | Zendy; Seiichiro Abe | Zendy; Yutaka Saito | Zendy; Hiroyuki Daiko | Zendy; Satoko Takizawa | Zendy; Yoshiaki Aoki | Zendy; Hiromi Sakamoto | Zendy; Shumpei Niida | Zendy; Fumitaka Takeshita | Zendy; Takahiro Fukuda | Zendy; Takahiro Ochiya | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Development and Validation of an Esophageal Squamous Cell Carcinoma Detection Model by Large-Scale MicroRNA Profiling

Author(s) -

Kazuki Sudo,

Ken Kato,

Juntaro Matsuzaki,

Narikazu Boku,

Seiichiro Abe,

Yutaka Saito,

Hiroyuki Daiko,

Satoko Takizawa,

Yoshiaki Aoki,

Hiromi Sakamoto,

Shumpei Niida,

Fumitaka Takeshita,

Takahiro Fukuda,

Takahiro Ochiya

Publication year - 2019

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2019.4573

Subject(s) - medicine , esophageal cancer , stage (stratigraphy) , oncology , cancer , receiver operating characteristic , biobank , microrna , population , bioinformatics , paleontology , biology , biochemistry , chemistry , environmental health , gene

Key Points Question Can circulating microRNAs be used as biomarkers to detect esophageal squamous cell carcinoma? Findings In this case-control study of 566 patients with esophageal squamous cell carcinoma and 4965 control patients without cancer, serum samples from patients with esophageal squamous cell carcinoma and control patients were used to establish a model to detect esophageal squamous cell carcinoma using 6 microRNAs in a training set. In the validation set, the model distinguished patients with cancer from control patients with high sensitivity and high specificity (0.96 and 0.98, respectively). Meaning The 6-microRNA model is a promising noninvasive screening tool in esophageal squamous cell carcinoma.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research