Assessment of Accuracy of Waterfall Plot Representations of Response Rates in Cancer Treatment Published in Medical Journals | Zendy

Myung Sun Kim | Zendy; Vinay Prasad | Zendy

Open Access

Assessment of Accuracy of Waterfall Plot Representations of Response Rates in Cancer Treatment Published in Medical Journals

Author(s) -

Myung Sun Kim,

Vinay Prasad

Publication year - 2019

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2019.3981

Subject(s) - waterfall , interquartile range , waterfall model , medicine , plot (graphics) , range (aeronautics) , statistics , mathematics , surgery , cartography , computer science , geography , engineering , software , aerospace engineering , programming language

Key Points Question How accurate are waterfall plots in representing overall response rates reported in clinical trials? Findings In this cross-sectional study of 126 studies published in 6 journals, waterfall plots showed visual response rates that were 6.1% higher compared with response rates based on investigator review and 12.0% higher compared with response rates based on central review. Use of waterfall plots has increased from 0% of original articles in 2004 to 7% in 2018. Meaning This study suggests that waterfall plots are used more frequently over time and exaggerate the visual estimate of the response rate.

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