Open AccessAssociation of Economic Status and Educational Attainment With Posttraumatic Stress Disorder
Author(s) -
Renato Polimanti,
Andrew Ratanatharathorn,
Adam X. Maihofer,
Karmel W. Choi,
Murray B. Stein,
Rajendra A. Morey,
Mark W. Logue,
Caroline M. Nievergelt,
Dan J. Stein,
Karestan C. Koenen,
Joel Gelernter
Publication year - 2019
Publication title -
jama network open
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.278
H-Index - 39
ISSN - 2574-3805
DOI - 10.1001/jamanetworkopen.2019.3447
Subject(s) - mendelian randomization , association (psychology) , genome wide association study , clinical psychology , genetic association , medicine , linkage disequilibrium , genetic correlation , psychology , psychiatry , population , genetic variation , single nucleotide polymorphism , genetics , genotype , biology , genetic variants , gene , psychotherapist , environmental health
Key Points Question Which mechanisms underlie the negative association of posttraumatic stress disorder (PTSD) with traits related to educational attainment (EA)? Findings In this mendelian randomization study based on large-scale genomic data sets, including data from more than 1 million individuals, EA was negatively associated with PTSD, also supporting the role of economic status as a mediator in this association. Meaning This study suggests that economic status may mediate the association of EA with PTSD independent of the brain mechanisms associated with EA.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom