Open AccessAssociation of Brain Magnetic Resonance Imaging Signs With Cognitive Outcomes in Persons With Nonimpaired Cognition and Mild Cognitive Impairment
Author(s) -
Aozhou Wu,
A. Richey Sharrett,
Rebecca F. Gottesman,
Melinda C. Power,
Thomas H. Mosley,
Clifford R. Jack,
David S. Knopman,
B. Gwen Windham,
Alden L. Gross,
Josef Coresh
Publication year - 2019
Publication title -
jama network open
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.278
H-Index - 39
ISSN - 2574-3805
DOI - 10.1001/jamanetworkopen.2019.3359
Subject(s) - dementia , hyperintensity , cognition , medicine , rotterdam study , magnetic resonance imaging , population , cohort study , cognitive decline , cohort , psychology , psychiatry , disease , environmental health , radiology
Key Points Question To what extent are magnetic resonance imaging–measurable brain lesions associated with dementia and mild cognitive impairment (MCI) among older people? Findings In this cohort study of 1553 participants, lower volumes in the Alzheimer disease signature region (hippocampus, entorhinal cortex, and surrounding structures), lobar microhemorrhages, and higher white matter hyperintensity volumes were independent risk factors for dementia and MCI. Findings suggested vascular changes were more important in the development of MCI than in its progression to dementia, whereas Alzheimer disease–related signs were important in both stages. Meaning Alzheimer disease–related and vascular-specific magnetic resonance imaging signs together may be associated with the further risk of dementia and MCI in an older population.
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