Open AccessAssociation of Malaria Infection During Pregnancy With Head Circumference of Newborns in the Brazilian Amazon
Author(s) -
Jamille Gregório Dombrowski,
Rodrigo Medeiros de Souza,
Flávia Afonso Lima,
Carla Letícia Bandeira,
Oscar Murillo,
Douglas de Sousa Costa,
Erika Paula Machado Peixoto,
Marielton dos Passos Cunha,
Paolo Marinho de Andrade Zanotto,
Estela Bevilacqua,
Marcos Grisotto,
Antonio Carlos Pedroso de Lima,
Júlio M. Singer,
Susana Campino,
Taane G. Clark,
Sabrina Epiphânio,
Lígia Antunes Gonçalves,
Cláudio Romero Farias Marinho
Publication year - 2019
Publication title -
jama network open
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.278
H-Index - 39
ISSN - 2574-3805
DOI - 10.1001/jamanetworkopen.2019.3300
Subject(s) - medicine , prospective cohort study , pregnancy , obstetrics , cohort , retrospective cohort study , malaria , cohort study , population , pediatrics , immunology , environmental health , biology , genetics
Key Points Question Is malaria infection during pregnancy associated with fetal head growth? Findings In 2 cohort studies of 4291 pregnancies, falciparum malaria during pregnancy was significantly associated with the occurrence of decreased head circumference in newborns. Placental malaria characterized by increased placental syncytial nuclear aggregates, leukocyte infiltration, and imbalanced angiogenic factors was associated with the incidence of decreased head circumference. Meaning Plasmodium falciparum infection during pregnancy was associated with altered fetal head development, with possible consequences for fetal neurologic development.
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