Molecular Profiling of Hard-to-Treat Childhood and Adolescent Cancers | Zendy

Fida Khater | Zendy; Stéphanie Vairy | Zendy; Sylvie Langlois | Zendy; Sophie Dumoucel | Zendy; Thomas Sontag | Zendy; Pascal St-Onge | Zendy; Henrique Bittencourt | Zendy; Dorothée Dal Soglio | Zendy; Josette Champagne | Zendy; Michel Duval | Zendy; JeanMarie Leclerc | Zendy; Caroline Laverdière | Zendy; Thai Hoa Tran | Zendy; Natalie Patey | Zendy; Benjamin Ellezam | Zendy; Sébastien Perreault | Zendy; Nelson Piché | Zendy; Yvan Samson | Zendy; Pierre Teira | Zendy; Nada Jabado | Zendy; Bruno Michon | Zendy; Josée Brossard | Zendy; Monia Marzouki | Zendy; Sonia Cellot | Zendy; Daniel Sinnett | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Molecular Profiling of Hard-to-Treat Childhood and Adolescent Cancers

Author(s) -

Fida Khater,

Stéphanie Vairy,

Sylvie Langlois,

Sophie Dumoucel,

Thomas Sontag,

Pascal St-Onge,

Henrique Bittencourt,

Dorothée Dal Soglio,

Josette Champagne,

Michel Duval,

JeanMarie Leclerc,

Caroline Laverdière,

Thai Hoa Tran,

Natalie Patey,

Benjamin Ellezam,

Sébastien Perreault,

Nelson Piché,

Yvan Samson,

Pierre Teira,

Nada Jabado,

Bruno Michon,

Josée Brossard,

Monia Marzouki,

Sonia Cellot,

Daniel Sinnett

Publication year - 2019

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2019.2906

Subject(s) - medicine , exome sequencing , kras , exome , targeted therapy , oncology , cancer , bioinformatics , gene , phenotype , colorectal cancer , genetics , biology

Key Points Question Can genome sequencing facilitate the molecular profiling of the patient's tumor to identify actionable and targetable alterations? Findings In this diagnostic study of 62 consecutive pediatric patients with hard-to-treat cancer who were enrolled in the TRICEPS study, incorporating multimodal genomic sequencing, including RNA sequencing, into the management of refractory or relapsed childhood and adolescent cancers identified potentially actionable alterations in 54 (87%) of patients. Meaning Molecular profiling may enable the identification of potentially actionable alterations with clinical implications for most patients tested, including targeted therapy and clinically relevant information of diagnostic, prognostic, and monitoring significance.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research