Association of Peritumoral Radiomics With Tumor Biology and Pathologic Response to Preoperative Targeted Therapy for HER2 (ERBB2)–Positive Breast Cancer | Zendy

Nathaniel Braman | Zendy; Prateek Prasanna | Zendy; Jon Whitney | Zendy; Salendra Singh | Zendy; Niha Beig | Zendy; Maryam Etesami | Zendy; ‬David D. B. Bates | Zendy; Katherine Gallagher | Zendy; B Bloch | Zendy; Manasa Vulchi | Zendy; Paulette Turk | Zendy; Kaustav Bera | Zendy; Jame Abraham | Zendy; William M. Sikov | Zendy; George Somlo | Zendy; Lyndsay N. Harris | Zendy; Hannah Gilmore | Zendy; Donna Plecha | Zendy; Vinay Varadan | Zendy; Anant Madabhushi | Zendy

Open Access

Association of Peritumoral Radiomics With Tumor Biology and Pathologic Response to Preoperative Targeted Therapy for HER2 (ERBB2)–Positive Breast Cancer

Author(s) -

Nathaniel Braman,

Prateek Prasanna,

Jon Whitney,

Salendra Singh,

Niha Beig,

Maryam Etesami,

‬David D. B. Bates,

Katherine Gallagher,

B Bloch,

Manasa Vulchi,

Paulette Turk,

Kaustav Bera,

Jame Abraham,

William M. Sikov,

George Somlo,

Lyndsay N. Harris,

Hannah Gilmore,

Donna Plecha,

Vinay Varadan,

Anant Madabhushi

Publication year - 2019

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2019.2561

Subject(s) - breast cancer , medicine , magnetic resonance imaging , oncology , cancer , neoadjuvant therapy , targeted therapy , trastuzumab , clinical trial , breast mri , chemotherapy , radiology , mammography

Key Points Question Can quantitative imaging features extracted from the tumor and tumor environment on breast magnetic resonance imaging characterize tumor biological features relevant to outcome of targeted therapy? Findings In this diagnostic study of 209 patients, among HER2 ( ERBB2 )-positive breast cancers, an intratumoral and peritumoral imaging signature capable of discriminating the response-associated HER2 -enriched molecular subtype was identified. When evaluated among recipients of HER2 -targeted therapy, this signature was found to be associated with response to neoadjuvant chemotherapy. Meaning Quantitative analysis of the tumor and its surroundings may provide valuable cues into breast cancer biological features and likelihood of response to targeted therapy.

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